Table 3.

Conjoint relations of TIMP-1 and PIIINP to the risk of death and CVD.

	Adjusted HR* (CI)	p-value
A. Death (n = 808; 44 events)
Log-TIMP-1	1.60 (1.19 – 2.15)	0.002
Log-PIIINP	1.41 (1.03 – 1.92)	0.03
B. CVD (n = 808; 64 events)
Log-TIMP-1	1.04 (0.79 – 1.37)	0.77
Log-PIIINP	1.35 (1.05 – 1.74)	0.02

HR = hazards ratio; CI = confidence interval; TIMP-1 = tissue inhibitor of matrix metalloproteinase; PIIINP = procollagen type III amino-terminal peptide.

^*HR per standard deviation change in biomarker levels, adjusted for age, sex, BMI, systolic blood pressure, hypertension treatment, diabetes, total/HDL cholesterol ratio, current smoking, LV mass and LV sampling group.