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Like all other immunoglobulins, IgE can be expressed as secreted Ab or as membrane-anchored receptor. The membrane form of IgE is coded by the variable domain exon, 4 constant domain exons (CH1-CH4), the transmembrane domain exon M1, and the cytoplasmic domain exon M2. The 19 amino acids of the EMPD, coded by M1, were used as target sequence for the generation of anti-EMPD specific Abs.
