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To show that mAbA9 blocks specific IgE synthesis during a passive immunization approach, mice of control group 1 (open circles) were immunized with the allergen Bet v1a on days 0, 7, 14, and 183. Group 2 (closed circles) was immunized as described for group 1 but additionally received monoclonal anti-EMPD Ab on days 3, 6, 9, 12, and 15. Each circle represents one individual mouse. Bet v1a-specific IgE (a) and IgG1 (b) titers were determined.
