Table 3.
Cytokine Concentrations by Per3 VNTR Genotypea
|
Per3 VNTR Genotype |
|||||||
|---|---|---|---|---|---|---|---|
| Cytokine Concentration (pg/mL) | 4/4 (n = 35) | 4/5 (n = 27) | 5/5 (n = 6) | 4/5 and 5/5 (n = 33) | 4/4 Versus 4/5 P Value | 4/4 Versus 5/5 P Value | 4/4 Versus 4/5 and 5/5 P Value |
| IL-6 | 34.1 | 52.8 | 66.7 | 54.8 | .09 | .13 | .05 |
| TNF-α | 1.3 | 0.9 | 2.7 | 1.1 | .32 | .23 | .66 |
| IFN-γ | 2.1 | 1.5 | 2.9 | 1.7 | .29 | .57 | .46 |
| IL-Ira | 3.5 | 3.0 | 6.5 | 3.4 | .70 | .33 | .95 |
| IL-I-β | 3.1 | 3.0 | 5.5 | 3.3 | .95 | .45 | .90 |
| VEGF | 904 | 880 | 1002 | 901 | .85 | .65 | .99 |
NOTES: VNTR, variable number tandem repeat; IL, interleukin; TNF, tumor necrosis factor; IFN, interferon; ra, receptor antagonist; VEGA, vascular endothelial growth factor.
a
Least squares means adjusted for covariates as follows: IL-6: family history of colon cancer, how often person feels stress, prior stressful event. TNF-α: fruit juice intake per week. IFN-γ: family history of colon cancer, fruit juice intake per week. IL-Ira: body mass index, diarrhea in the past 6 months, fruit juice intake per week. IL-I-β: body mass index, circadian type. VEGF: use of nonsteroidal anti-inflammatory drugs, unable to visit doctor due to cost, packs of cigarettes smoked per day.