Table 4.

Circadian Disruption Symptoms by Per3 VNTR Genotype^a

	Per3 VNTR Genotype
Symptom	4/4 (n = 35)	4/5 (n = 27)	5/5 (n = 6)	4/5 and 5/5 (n = 33)	4/4 Versus 4/5 P Value	4/4 Versus 5/5 P Value	4/4 Versus 4/5 and 5/5 P Value
Depressive symptoms	15.3	19.5	18.6	19.3	.08	.38	.07
Sleep quality	9.3	7.4	9.8	7.9	.06	.79	.11
General fatigue	12.2	12.6	11.4	12.4	.38	.36	.65
Physical fatigue	12.0	11.0	11.4	11.1	.03	.43	.03
Mental fatigue	12.5	12.4	11.6	12.2	.83	.15	.52
Reduced motivation	11.7	12.5	12.6	12.5	.15	.39	.13
Reduced activity	11.9	11.5	11.2	11.5	.37	.34	.29

NOTES: Per, Period; VNTR, variable number tandem repeat.

^aLeast squares means adjusted for covariates as follows: Beck Depression Inventory II: diarrhea in the past 6 months, how often person feels stress, posttraumatic stress disorder. Pittsburgh Sleep Quality Index: personal cancer history, spouse kicks or moves during sleep, how often person feels stress, soft drink intake per week. Multidimensional Fatigue Inventory: General fatigue—personal cancer history, diarrhea in the past 6 months, tea intake per week. Physical fatigue—calcium supplement intake per day, bacon intake per week. Mental fatigue—number of dependents, personal cancer history, cigarettes smoked per day. Reduced motivation—diagnosed inflammatory illness, months reported being tired, frequency of stress, weekly intake of French fries. Reduced activity—age, number of months feeling like a failure.