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PGC-1α−/− significantly exacerbates chronic TAC-induced LV hypertrophy and fibrosis. Chronic TAC caused greater LV hypertrophy (A) and pulmonary congestion (B) in PGC-1α−/− as compared with wild-type mice. Chronic TAC causes similar degree of LV fibrosis (C, E), but more cardiac myocyte hypertrophy (D, F) in PGC-1α−/− as compared with wild-type mice. *p < 0.05 compared to the corresponding control; #p < 0.05 compared to Wt-TAC.
