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. 2010 Oct 1;13(7):1011–1022. doi: 10.1089/ars.2009.2940

FIG. 6.

FIG. 6.

SOD mimetic MnTMPyP significantly attenuated TAC-induced LV hypertrophy, dysfunction, and increase of LV oxidative stress in PGC-1α−/− mice. SOD mimetic MnTMPyP significantly attenuated TAC-induced LV hypertrophy (A) and LV dysfunction (B–D) in PGC-1α−/− mice. *p < 0.05 compared to TAC group; MnTMPyP also attenuated TAC induced the decrease of citrate synthase activity (E) and increase of ANP and 3’-NT content (F–I). The potential signaling pathways for the exacerbated LV myocardial oxidative stress and heart failure in PGC-1α−/− mice are summarized in panel (J). *p < 0.05 compared to the control; #p < 0.05 compared to TAC group.