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. 2010 Oct 1;13(7):987–997. doi: 10.1089/ars.2009.2896

FIG. 3.

FIG. 3.

Cis-bixin–induced cytotoxicity in myeloma cells is associated with apoptosis. (A) Electron microscopic images (×2,500) of OCI-MY-5 myeloma cells treated with DMSO diluent or 200 μM cis-bixin, demonstrating induction of morphologic apoptosis (arrows). (B) Concentration-dependence of apoptosis induction by cis-bixin in OCI-MY-5 myeloma cells. Apoptosis was assessed with Hoechst 33258 nuclear staining after 24-h exposures to indicated cis-bixin concentrations; error bars indicate ±1 standard deviation. (C) Cis-bixin induces PARP cleavage in OCI-MY-5 cells (24-h drug exposures).