TABLE 1.

NLSs characterized in papillomaviruses

Virus	Viral protein	NLS sequence(s)a	Reference or source
HPV5	E2	246RGRRYGRRPSSKSRRSQTQQRRSRSRHRSRSRSRSRSKSQTHTTWSTTRSRSTSVGKTRALTSRSRSRGRSPSTCRRGGGRSPRRRSR333	35
HPV6b	L2	5RARRRKR11	71
		444RKRRKR449
HPV11	E2	238RKRAR242	79
	L1	481KRPAVSKPSTAPKRKRTKTKK501	50
HPV16	E6	8RPRK11	This study
		65KCLKFYSK72
		115KQRHLDKKQR124
	E7b	17PETTDLYCYEQLNDSSEEEDEIDGP41	15
	L1	510KRKATPTTSSTSTTAKRKKRK530	77
HPV45	L1	505RRRPTIGPRKRPAASTSTASTASRPAKRVRIRSKK539	50
Bovine papillomavirus type 1	E1	84KRKVLGSSQNSSGSEASETPVKRRK108	38
	E2	106PKRCFKKGAR115	64
		340KCYRFRVKKNHRHR353

^aBold type indicates basic residues.

^bHPV16 E7 has no obvious NLS, and the mechanism by which wild-type E7 is targeted to the nucleus is unknown. The sequence presented here was suggested by deletion mutation analysis (15).