FIG. 2.

Pseudoinfection in the presence of heparin derivatives. COS7 cells were incubated with pseudovirions in the presence of heparin derivatives at the indicated concentrations. Infectious events were monitored for 72 h postinfection. The number of green fluorescent cells in the absence of inhibitors was set as 100%. Mean values of three independent experiments are shown. (A) Effect of heparin derivatives (H-4776, A-6039, and A-8036) compared to unmodified heparins (H-4784 and H-5284) of various molecular weights. (B) Concentration dependence of the inhibitory effect of heparin derivatives. A value of 100% infectivity corresponds to 370 infected cells.