FIG. 5.

Reactivity of monoclonal antibodies with HPV33 L1L2 pseudovirions. (A) Interaction of H33.J3 and H33.B6 with heparin-bound pseudovirions. (B) Interaction of monoclonal antibodies with pseudovirions in solution. Pseudovirions were incubated with magnetic beads loaded with the indicated monoclonal antibody. After removal of beads, supernatants were tested for residual infectivity. All HPV33-specific conformation-dependent monoclonal antibodies, but not a control monoclonal antibody (c.mAb), efficiently depleted pseudovirions.