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Effect of compound A on parental and resistant clones
| Clone | IC50 (μM) for compound Aa
|
NS5B mutation(s) | |
|---|---|---|---|
| Cell-ELISA | isRPA | ||
| HBI10A | 0.35 ± 0.15 | 0.30 ± 0.2 | |
| 10AI1 | >5 | >5 | P495L |
| 10AI2 | >5 | >5 | P495L |
| 10AI12 | >5 | >5 | P495A |
| 10AI14 | >5 | >5 | P495L, 1585T |
Data are means ± standard deviations.
