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Resistant replicons and enzyme
| Replicon or enzyme | NS5B mutation(s) | Replication efficiency (arbitrary units)a | IC50 (μM)
|
||
|---|---|---|---|---|---|
| Compound A | Compound B | ||||
| pHCVNEO17 replicons
|
|||||
| B | 14.2 | 0.32 | |||
| BR1 | P495L | 3.1 | >5 | ||
| BR2 | P495A | 10.9 | 2.2 | ||
| D | I585T | >20 | 0.4 | ||
| DR1 | P495L, I585T | 10.6 | >5 | ||
| Enzyme ΔC55 | |||||
| P495L | >20 | 16 ± 0.8 | |||
Replication efficiency was determined by cell-ELISA.
