TABLE 1.

Analysis of recombinant viruses indicates that ts138 is an nsP3 mutant

Virus	Fragment replaced (nt)	EOP (PFU at 40°C/PFU at 30°C)	Growth
ts138		2 × 10−4	ts
138R		7 × 10−1	wta
Toto:ts138SC	1-2713	3 × 10−1	wt
Toto:ts138BBs	2288-4318	0.1 × 10−5-3 × 10−5	ts
Toto:ts138BN	2288-3734	3 × 10−1-9 × 10−1	wt
Toto:ts138NA	3734-4280	4 × 10−1-6 × 10−1	wt
Toto:ts138ABs	4280-4318	2 × 10−4	ts
Toto:ts138BN+NA	2288-4280	1 × 10−1-5 × 10−1	wt

^awt, wild type.