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. 2003 Dec;77(24):13301–13314. doi: 10.1128/JVI.77.24.13301-13314.2003

FIG.2.

FIG.2.

FIG.2.

CMV replicates in diverse cell types in maternal uterine decidua. (A) CMV infects endometrial glands (GLD), uterine blood vessels (BV), resident decidual cells (DecC) and cytotrophoblasts (CTB) in the decidua. a to c, Decidual biopsy specimens stained for CMV-infected cell proteins (ICP, green) and cytokeratin (CK, red) in epithelial cells (EpC). d to i, CMV-infected interstitial and endovascular CTB and DecC. j to l, Endothelial cells (EnC) and smooth muscle cells (SMC) of uterine blood vessels (BV) are infected. Merged, colocalized proteins (yellow). Large arrowheads, insets. (B) Abundant innate immune cells infiltrating the decidua contain CMV proteins. a to c, CMV gB (green), macrophages (Mφ/DC, CD68, red). d to f, DC-SIGN-positive (green) macrophage/dendritic cells (Mφ/DC) take up CMV gB (red). g and h, CD56-positive (green) natural killer (NK) cells each target infection sites. i, DC-SIGN-positive cells containing gB. j to l, Neutrophils (PMN) with phagocytosed proteins from virus-infected cells and endothelial cells (EnC) positive for von Willebrand factor (vWF) in blood vessels (BV). Merged, colocalized proteins (yellow). Large arrowheads, insets.