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Regions of the D2O NOESY spectrum showing NOEs from benzene protons facing into the groove to DNA protons of the ligand A/A3T3 complex, 200 ms mixing time. (A) Ligand protons B1 and B5 to DNA H1′ contacts; note that nearly all of the NOEs are to thymidines. (B) Ligand to adenine H2 contacts. Both B1 and B5 have NOEs to more than one nucleotide in both regions.
