TABLE 2.
Resection time and linezolid concentration in tissue samples
| Tissue | Timea (min)
|
nb | Linezolid concn (mg/liter)
|
||
|---|---|---|---|---|---|
| Mean ± SD | Range | Mean ± SD | Range | ||
| Fascia | 48 ± 26 | 35-100 | 10 | 13.1 ± 5.4 | 5.6-23.7 |
| Joint capsule | 49 ± 10 | 35-62 | 7 | 12.6 ± 2.9 | 7.6-16.3 |
| Bone (cancellous) | 54 ± 18 | 35-89 | 11 | 3.9 ± 2.0 | 1.2-8.3 |
| Bone marrow | 71 ± 35 | 35-124 | 5 | 10.5 ± 2.2 | 8.0-14.1 |
| Granulation tissue (periprosthetic) | 55 ± 10 | 43-70 | 7 | 13.6 ± 7.7 | 7.9-30.1 |
| Granulation tissue | 61 ± 37 | 35-87 | 2 | 10.3 ± 1.4 | 9.3-11.3 |
| Subcutis | 49 ± 19 | 35-62 | 3 | 13.2 ± 1.1 | 12.0-14.1 |
| Tendon | 84 ± 50 | 49-119 | 2 | 14.5 ± 3.5 | 12.0-16.9 |
| Plasma | 54 ± 19 | 35-89 | 13 | 17.1 ± 5.1 | 11.1-26.6 |
a
Time after start of linezolid infusion.
b
n = number of tissue specimens from different patients.