TABLE 1.

Single-dose compartmental pharmacokinetic parameters of LNYS and DAMB in plasma^a,b

Cohort and dose (mg/kg)	Cmax (μg/ml)	Cmin (μg/ml)	AUC0-24 (μg·h/ml)	V1 (liter/kg)	V2 (liter/kg)	V3 (liter/kg)	Vss (liters/kg)	CL2 (liter/h/kg)	CL3 (liter/h/kg)	CLt (liter/h/kg)	t1/2α (h)	t1/2β (h)	t1/2γ (h)
LNYS
2	17.00 ± 0.62	ND	17.08 ± 0.48	0.093 ± 0.003	0.063 ± 0.001	NA	0.155 ± 0.003	0.1260 ± 0.019	NA	0.1173 ± 0.003	0.17 ± 0.01	1.10 ± 0.00	NA
4	39.27 ± 0.79	ND	42.74 ± 5.25	0.075 ± 0.001	0.063 ± 0.004	NA	0.138 ± 0.003	0.1233 ± 0.010	NA	0.0928 ± 0.012	0.16 ± 0.00	1.26 ± 0.09	NA
6	56.01 ± 0.42	ND	77.12 ± 9.65	0.085 ± 0.000	0.059 ± 0.002	NA	0.145 ± 0.002	0.1365 ± 0.006	NA	0.0805 ± 0.010	0.16 ± 0.01	1.44 ± 0.18	NA
DAMB, 1	3.36 ± 0.42	0.25 ± 0.03	12.23 ± 0.95	0.241 ± 0.040	0.631 ± 0.002	0.3306 ± 0.027	1.200 ± 0.043	0.2016 ± 0.015	0.4906 ± 0.040	0.0552 ± 0.007	0.16 ± 0.01	1.15 ± 0.07	16.82 ± 1.60

^aAll values represent the means ± SEM of results for three rabbits each. C_min, concentration in plasma at the end of the recommended dosing interval (24 h); V₁, V₂, V₃, volume of distribution of the first, second, and third compartment, respectively; CL₂, CL₃, distribution clearances; t_1/2α, distributional half-life; t_1/2β, apparent elimination half-life; t_1/2γ, terminal elimination half-life; ND, not detectable; NA, not applicable.

^bP values (based on Kruskal-Wallis nonparametric ANOVA): for C_max, <0.0001; for AUC_0-24, <0.0001; for V₁, <0.0001; for V₂, <0.0382; for V_ss, 0.0028; for CL₂, 0.0599; for CL_t, 0.0137; for t_1/2α, 0.9006; for t_1/2β, 0.2775.