TABLE 2.
Group and dose (mg/kg) | CmaxU (μg/ml) | TmaxU (h) | AUC0-24U (μg · h/ml) | CLR (liter/kg/h) |
---|---|---|---|---|
LNYS | ||||
2 | 16.83 ± 3.54 | 3.33 ± 1.33 | 63.12 ± 18.84 | 0.0081 ± 0.001 |
4 | 18.52 ± 4.85 | 2.67 ± 0.66 | 60.71 ± 8.68 | 0.0036 ± 0.000 |
6 | 10.00 ± 0.89 | 6.00 ± 1.15 | 35.27 ± 6.89 | 0.0028 ± 0.000 |
DAMB, 1 | 0.962 ± 0.352 | 12.67 ± 6.36 | 8.95 ± 3.14 | 0.0039 ± 0.001 |
All values represent the means ± SEM of results for three rabbits each.
bComparison among dosage groups was done by Kruskal-Wallis nonparametric ANOVA. P values: for CmaxU, 0.0152; TmaxU, 0.2541; AUC0-24U, 0.0152; CLR, 0.0681.