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. 2003 Dec;47(12):3917–3925. doi: 10.1128/AAC.47.12.3917-3925.2003

TABLE 2.

Single-dose pharmacokinetic parameters of LNYS and DAMB in urinealegend

Group and dose (mg/kg) CmaxU (μg/ml) TmaxU (h) AUC0-24U (μg · h/ml) CLR (liter/kg/h)
LNYS
    2 16.83 ± 3.54 3.33 ± 1.33 63.12 ± 18.84 0.0081 ± 0.001
    4 18.52 ± 4.85 2.67 ± 0.66 60.71 ± 8.68 0.0036 ± 0.000
    6 10.00 ± 0.89 6.00 ± 1.15 35.27 ± 6.89 0.0028 ± 0.000
DAMB, 1 0.962 ± 0.352 12.67 ± 6.36 8.95 ± 3.14 0.0039 ± 0.001
a

All values represent the means ± SEM of results for three rabbits each.

legend

bComparison among dosage groups was done by Kruskal-Wallis nonparametric ANOVA. P values: for CmaxU, 0.0152; TmaxU, 0.2541; AUC0-24U, 0.0152; CLR, 0.0681.