TABLE 4.
Recoveries of LNYS and DAMB from tissues and fluids 24 h after administration of a single dosea
| Tissue or fluid | % Recovery of drug after administration of dose indicated
|
P valueb | |||
|---|---|---|---|---|---|
| LNYS
|
DAMB, 1 μg/ml | ||||
| 2 μg/ml | 4 μg/ml | 6 μg/ml | |||
| Liver | 0.285 ± 0.005 | 0.248 ± 0.031 | 0.180 ± 0.021 | 25.87 ± 3.57 | 0.0028 |
| Spleen | 0.125 ± 0.064 | 0.085 ± 0.014 | 0.069 ± 0.008 | 0.351 ± 0.06 | 0.1364 |
| Kidney | 0.128 ± 0.008 | 0.206 ± 0.024 | 0.207 ± 0.033 | 0.988 ± 0.090 | 0.0020 |
| Lung | 0.065 ± 0.015 | 0.036 ± 0.001 | 0.035 ± 0.003 | 0.643 ± 0.150 | 0.0234 |
| Muscle | 0.000 ± 0.000 | 0.000 ± 0.000 | 0.000 ± 0.000 | 1.230 ± 0.272 | NA |
| Fat | 0.000 ± 0.000 | 0.000 ± 0.000 | 0.000 ± 0.000 | 0.000 ± 0.000 | NA |
| Brain | 0.000 ± 0.000 | 0.000 ± 0.000 | 0.000 ± 0.000 | 0.006 ± 0.001 | NA |
| Plasma | 0.000 ± 0.000 | 0.000 ± 0.000 | 0.000 ± 0.000 | 1.130 ± 0.837 | NA |
| Urine | 6.772 ± 0.772 | 3.730 ± 0.184 | 3.628 ± 0.683 | 4.697 ± 0.910 | 0.0788 |
a
Values represent means ± SEM of results for three treated and six untreated animals each.
b
P values are for the comparison among dosage groups by Kruskal-Wallis nonparametric ANOVA. NA, not applicable.