TABLE 1.

In vitro MICs and MBCs of tigecycline and comparative antibiotics against 68 planktonic and adherent S. epidermidis isolates

Antimicrobial agent	Planktonic bacteria (μg/ml)						Adherent bacteria (μg/ml)
	MIC range	MIC50	MIC90	MBC range	MBC50	MBC90	MICadh range	MIC50adh	MIC90adh	MBCadh range	MBC50adh	MBC90adh
Tigecycline	0.06-1	0.5	0.5	0.12->32	4	32	≤0.015-1	0.25	0.5	1-8	4	8
Minocycline	0.06-1	0.5	1	0.25->32	8	32	≤0.015-2	0.25	0.5	1-16	4	8
Vancomycin	1-8	2	4	1-16	4	8	≤0.015-4	2	4	2->32	16	32
AC98-6446	0.06-2	0.25	0.5	0.06-4	0.5	1	0.12-2	1	2	1-8	2	4
Daptomycin	0.5-8	1	2	0.5-64	1	4	0.06-4	1	2	0.5-64	4	32
Teicoplanin	0.12-8	2	8	0.25-16	4	16	0.06-4	1	4	0.5-32	4	8
Gentamicin	≤0.015->32	0.25	>32	0.03->32	32	>32	≤0.015-32	4	>32	0.12->32	32	>32
Tobramycin	0.06->32	16	>32	0.06->32	32	>32	0.06->32	8	>32	0.12->32	>32	>32
Ciprofloxacin	0.06->32	0.25	32	0.12->32	0.5	>32	0.06->32	0.25	32	0.5->32	2	>32
Oxacillin	≤0.06->128	4	128	0.06->128	8	>128	≤0.06->128	2	128	0.12->128	16	>128
Cefazolin	≤0.06->128	2	32	≤0.06->128	2	128	≤0.06->128	1	16	0.5->128	16	128
Rifampin	≤0.015->8	≤0.015	>8	≤0.015->8	0.03	>8	≤0.015->8	≤0.015	>8	≤0.015->8	0.03	>8
SXTa	0.12->128	2	64	4->128	>128	>128	0.12-128	1	64	1->128	>128	>128

^aSXT, trimethoprim-sulfamethoxazole.