TABLE 1.
Pharmacokinetic data in the IVIEMa
| Drug and dosing regimene | Concn (μg/ml)b
|
t1/2 (h)c | ||
|---|---|---|---|---|
| Cpeak | Ctrough | Cpssd | ||
| VAN | ||||
| CI | 20.6 ± 0.7 | 5.8 ± 0.2 | ||
| q6h | 25.6 ± 3.2 | 8.9 ± 1.1 | 5.5 ± 0.5 | |
| q12h | 32.4 ± 2.8 | 6.1 ± 1.7 | 7.0 ± 0.6 | |
| q24h | 68.3 ± 2.1 | 8.2 ± 2.1 | 6.0 ± 0.4 | |
| ABK | ||||
| q12h | 11.6 ± 0.7 | 0.76 ± 0.2 | 3.0 ± 0.2 | |
| q24h | 18.0 ± 0.9 | 0.18 ± 0.1 | 3.6 ± 0.3 | |
| GEN | ||||
| q8h | 7.3 ± 1.3 | 1.1 ± 0.3 | 2.9 ± 0.5 | |
| q24h | 17.2 ± 1.9 | 0.2 ± 0.1 | 3.7 ± 0.3 | |
a
All values are means ± standard deviations (n = 4).
b
Concentrations at steady state.
c
t1/2, half-life.
d
Cpss, peak concentration at steady state.
e
Abbreviations: VAN, vancomycin; ABK, arbekacin; GEN, gentamicin; CI, continuous infusion; q6h, every 6 h; q8h, every 8 h; q12h, every 12 h; q24h, every 24 h.