TABLE 2.
Pharmacodynamic data in the IVIEMa
| Drug and dosing regimenc | Result for strain:
|
|||||
|---|---|---|---|---|---|---|
| GR153
|
GS171
|
|||||
| T > MIC (%)b | AUC0-24/MIC | Cmax/MIC | T > MIC (%) | AUC0-24/MIC | Cmax/MIC | |
| VAN | ||||||
| CI | 100 | 494.4 ± 9.5 | NDd | 100 | 988.8 ± 4.8 | ND |
| q6h | 100 | 562.8 ± 4.9 | ND | 100 | 1,124.7 ± 5.6 | ND |
| q12h | 100 | 465.9 ± 3.1 | ND | 100 | 931.8 ± 5.7 | ND |
| q24h | 100 | 798.7 ± 8.2 | ND | 100 | 1,597.4 ± 6.9 | ND |
| ABK | ||||||
| q12h | ND | 102.4 ± 1.0 | 11.6 ± 0.7 | ND | 204.9 ± 1.8 | 22.9 ± 0.9 |
| q24h | ND | 94.0 ± 2.2 | 18.0 ± 0.9 | ND | 198.1 ± 1.5 | 37.2 ± 0.6 |
| GEN | ||||||
| q8h | ND | 2.9 ± 0.9 | 0.2 ± 0.1 | ND | 375.6 ± 2.8 | 29.2 ± 1.8 |
| q24h | ND | 2.9 ± 0.5 | 0.5 ± 0.2 | ND | 372.8 ± 1.6 | 68.8 ± 2.1 |
a
All values are means ± standard deviations (n = 4).
b
T > MIC, percentage of time that the drug concentration was above the MIC.
c
Abbreviations: VAN, vancomycin; ABK, arbekacin; GEN, gentamicin; CI, continuous infusion; q6h, every 6 h; q8h, every 8 h; q12h, every 12 h; q24h, every 24 h.
d
ND, not done.