TABLE 3.

Residual organisms at 8 and 72 h in bacterial inocula in the IVIEM^a

Antibiotic regimenb	Log10 CFU/g
	GR153		GS171
	8 h	72 h	8 h	72 h
Growth control	11.90 ± 0.11	12.40 ± 0.30	11.89 ± 0.10	12.42 ± 0.31
VAN
CI	8.36 ± 0.07c	6.25 ± 0.50c	5.94 ± 0.01c,d	6.28 ± 0.01c
q6h	7.01 ± 0.25c	6.12 ± 0.32c	7.37 ± 0.07c,d	6.20 ± 0.07c
q12h	8.22 ± 0.22c	6.00 ± 0.77c	6.20 ± 0.30c,d	6.30 ± 0.21c
q24h	7.76 ± 0.13c	5.90 ± 0.40c	5.81 ± 0.10c,d	5.92 ± 0.10c
ABK
q12h	7.64 ± 0.22c	6.31 ± 0.10c	4.56 ± 0.053c,d,e	6.20 ± 0.77c
q24h	8.45 ± 0.17c	6.19 ± 0.30c	6.47 ± 0.16c,d	6.00 ± 0.04c
GEN
q8h	10.90 ± 0.50	12.14 ± 0.21	5.17 ± 0.16c,d	6.18 ± 0.27c
q24h	11.60 ± 0.80	12.10 ± 0.59	5.93 ± 0.13c,d	4.75 ± 0.83c,f
VAN q12h + ABK q24h	7.10 ± 0.19c	5.72 ± 0.85c	6.03 ± 0.92c,d	5.76 ± 0.27c
VAN q12h + GEN q24h	7.80 ± 0.50c	5.48 ± 0.18c	5.54 ± 0.09c,d	4.69 ± 0.18c

^aAll values are means ± standard deviations (n = 4).

^bCI, continuous infusion; VAN, vancomycin; ABK, arbekacin; GEN, gentamicin; q6h, every 6 h; q8h, every 8 h; q12h, every 12 h; q24h, every 24 h.

^cStatistically significantly different from growth control (P < 0.0001).

^dStatistically significantly different from colony count of GR153 at 8 h (P = 0.02).

^eStatistically significantly different from colony count of GR153 and GS171 at 8 h (P = 0.01).

^fStatistically significantly different from arbekacin q24h in GS171 at 72 h (P = 0.04).