TABLE 1.
Effect of moxifloxacin on production of TNF-α by PBMCsa
Treatment | TNF-α concn (pg/ml) with the following stimulus:
|
|||
---|---|---|---|---|
LPS | E. coli | LTA | S. pneumoniae | |
Stimulus only | 3,066 ± 249 | 1,372 ± 175 | 341 ± 30 | 1,159 ± 63 |
Stimulus and: | ||||
moxifloxacin (10 μg/ml) | 1,072 ± 23b | 720 ± 75b | 164 ± 22b | 912 ± 97 |
levofloxacin (10 μg/ml) | 1,472 ± 45b | 908 ± 322 | 209 ± 82 | 920 ± 132 |
ceftriaxone (250 μg/ml) | 1,208 ± 237b | 1,076 ± 16 | 264 ± 54 | 917 ± 433 |
The concentrations were measured by ELISA. The values are means ± standard errors of the means for quadruplicate measurements.
P < 0.05 compared to the result for each stimulus only.