TABLE 2.
Pharmacokinetic indices for linezolid and ciprofloxacin in volunteersa
| Drug and parameter | Cmax (μg/ml) | Tmax (h) | t1/2 (h) | MRT (h) | AUC0-last (μg · h/ml) | AUC0-∞ (μg · h/ml) | CL (ml/min) | CLR (ml/min) | CLNR (ml/min) | Vβ (liter) | Vss (liter) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Linezolid | |||||||||||
| Mean | 13.1 | 1.42 | 6.16 | 8.94 | 109.5 | 118.6 | 87.88 | 34.6 | 53.2 | 46.0 | 46.2 |
| SD | 1.80 | 0.51 | 1.41 | 2.07 | 22.48 | 26.41 | 17.71 | 8.33 | 14.8 | 11.3 | 10.6 |
| CV (%) | 13.8 | 36.3 | 22.9 | 23.1 | 20.5 | 22.3 | 20.16 | 24.05 | 27.9 | 24.5 | 23.0 |
| Minimum | 10.5 | 1.00 | 4.29 | 6.11 | 81.89 | 83.56 | 57.75 | 22.8 | 31.3 | 32.2 | 33.9 |
| Maximum | 15.6 | 2.00 | 8.68 | 12.91 | 159.0 | 173.1 | 119.7 | 48.0 | 86.1 | 64.8 | 64.8 |
| Median | 13.3 | 1.00 | 6.09 | 8.80 | 106.2 | 110.8 | 90.30 | 32.5 | 52.7 | 44.6 | 44.3 |
| Ciprofloxacin | |||||||||||
| Mean | 2.46 | 1.09 | 4.40 | 5.31 | 10.2 | 10.4 | 1,001 | 336.8 | 664.5 | 380.3 | 316.1 |
| SD | 0.481 | 0.29 | 0.56 | 0.56 | 1.90 | 1.95 | 220.2 | 138.1 | 131.6 | 91.92 | 60.78 |
| CV (%) | 19.5 | 26.4 | 12.8 | 10.6 | 18.7 | 18.8 | 22.0 | 41.0 | 19.8 | 24.4 | 19.2 |
| Minimum | 1.61 | 1.00 | 3.75 | 4.41 | 6.41 | 6.52 | 747.5 | 145.2 | 444.1 | 275.2 | 239.9 |
| Maximum | 3.18 | 2.00 | 5.79 | 6.24 | 13.1 | 13.4 | 1534 | 721.9 | 914.8 | 578.0 | 453.0 |
| Median | 2.50 | 1.00 | 4.20 | 5.31 | 10.5 | 10.7 | 933.7 | 309.3 | 680.9 | 353.5 | 298.7 |
a
A total of 12 volunteers were tested. Abbreviations: AUC0-last, AUC from time zero to the last 36 h; AUC0-∞, AUC from time zero to infinity; CV, coefficient of variation. The other abbreviations are defined in the text.