TABLE 3.
Urinary pH and volume, parent drug concentration in urine and cumualtive excretion in the volunteersa
| Drug and collection period (h) | Urinary pH | Vol (ml) | Concn (mg/liter) | % Cumulative excretion
|
|
|---|---|---|---|---|---|
| Median (range) | Mean ± SD | ||||
| Linezolid | |||||
| 0-6 | 5.9c (5.2-6.5) | 532 (182-1,135) | 192.0c (104-497) | 16.9c (10.0-26.6) | 17.0 ± 5.0 |
| 6-12 | 7.7 (6.2-8.7) | 947 (515-1,353) | 82.0c (66-163) | 30.6c (19.5-40.4) | 29.7 ± 6.5 |
| 12-24 | 6.3 (5.5-7.1) | 824 (413-954) | 61.0c (37-139) | 40.4 (26.6-45.6) | 37.0 ± 7.1 |
| 24-36 | 6.7 (5.6-8.0) | 1,236 (432-3,160) | 7.8c (5.3-51) | 43.4 (28.1-46.5) | 39.3 ± 7.7 |
| 36-48 | 6.2c (5.7-6.6) | 712 (334-1,630) | 3.1c (1.2-9.4) | 43.7 (28.2-46.7) | 39.7 ± 7.7 |
| 48-72 | 6.3 (5.6-7.0) | 1,432 (784-2,450) | 0.6d (0.2-4.3) | 43.9 (28.2-47.1) | 39.9 ± 7.8 |
| 72-96 | 6.0 (5.8-6.8) | 1,661 (784-3,132) | 0.1d (0.1-1.0) | 43.9 (28.2-47.2) | 39.9 ± 7.8 |
| 96-120 | 6.1 (5.2-8.5) | 1,333 (684-2,241) | 0.1d (0.02-0.2) | 43.9 (28.2-47.2) | 39.9 ± 7.8 |
| Ciprofloxacin | |||||
| 0-6 | 6.1c (5.4-6.5) | 353 (170-1,628) | 407.0c (23-733) | 31.5c (7.5-50.2) | 30.5 ± 10.3 |
| 6-12 | 7.2 (6.2-8.9) | 643 (376-1,485) | 47.0c (19-76) | 38.6c (14.9-53.9) | 36.5 ± 9.7 |
| 12-24 | 6.3 (5.9-7.7) | 575 (410-1,543) | 24.0c (5.8-36) | 41.4 (18.9-55.5) | 39.0 ± 9.3 |
| 24-36 | 7.0 (5.6-8.3) | 1,096 (566-2,213) | 2.0c (0.9-4.9) | 42.0 (19.4-56.0) | 39.5 ± 9.3 |
| 36-48 | 6.5c (5.8-8.0) | 709 (474-1,163) | 1.6c (0.6-3) | 42.2 (19.7-56.1) | 39.8 ± 9.3 |
| 48-72 | 6.1 (5.4-7.0) | 1,688 (864-2,042) | BQLb,d (BQL-1.6) | 42.6 (19.7-56.1) | 39.9 ± 9.3 |
| 72-96 | 6.1 (5.5-7.8) | 1,448 (570-2,697) | BQLd | 42.6 (19.7-56.1) | 39.9 ± 9.3 |
| 96-120 | 6.5 (5.7-8.0) | 1,299 (544-2,535) | BQLd (BQL-0.6) | 42.6 (19.7-56.1) | 39.9 ± 9.3 |
a
A total of 12 volunteers were tested. The values are given as medians (ranges) unless indicated otherwise.
b
BQL, below quantification limit (0.0098 mg/liter for linezolid; 0.559 mg/liter for ciprofloxacin).
c
Significantly different (P < 0.05) for linezolid versus ciprofloxacin.
d
Calculation not applicable.