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Terbinafine-resistant mutants with single base pair exchanges leading to amino acid substitutions in the Erg1 protein
| Mutant | Base pair exchange in ERG1 gene | Amino acid substitution in Erg1 protein |
|---|---|---|
| A2M8, H1A, H5, ML3a | C751T | L251F |
| H2 | C1206A | F402L |
| H1B | C1260A | F420L |
| H3, H4, H6, H7, H8 | C1288T | P430S |
| NS2a | T1298C | F433S |
Alleles ML3 and NS2 for terbinafine resistance were isolated after in vitro PCR mutagenesis of the ERG1 gene.
