TABLE 1.
Semiquantitative results of organ cultures of mice treated with antifungal therapy begun 24 h after challenge and sacrificed 24 h after completion of therapy
| Treatment (no. of animals) | Mean log10 no. of CFU/g (CI)a
|
||
|---|---|---|---|
| Kidneys | Spleen | Brain | |
| Control (9) | 4.49 (4.24-4.73) | 4.64 (4.30-5.04) | 5.55 (5.29-5.80) |
| AMB, 0.8 mg/kg (5) | 5.14 (4.53-5.73) | 4.82 (4.49-5.13) | 5.68 (5.40-5.97) |
| VRC, 5 mg/kg (4) | 4.43 (3.71-5.14) | 4.27b,c (3.67-4.87) | 4.91b,c (3.54-6.27) |
| VRC, 20 mg/kg (5) | 3.92b,c (3.65-4.18) | 4.25b,c (3.88-4.61) | 4.65b,c (4.09-5.20) |
| VRC, 40 mg/kg (9) | 3.39 (0.87-5.91) | 3.83b,c (3.12-4.54) | 4.25b,c (3.77-4.74) |
a
CI, confidence interval.
b
P < 0.05 versus AMB-treated group.
c
P < 0.05 versus control group.