TABLE 1.
Protective effects of DQ-113, gatifloxacin, and ciprofloxacin against mice infected with S. pneumoniae
| Infection | Drug | MIC (μg/ml) | ED50 (mg/kg/day) (95% confidence interval) |
|---|---|---|---|
| PSSPa | DQ-113 | 0.008 | 6.010 (1.989-9.895) |
| Gatifloxacin | 0.25 | 41.27 (27.91-59.46) | |
| Ciprofloxacin | 1.0 | 131.6 (95.61-173.2) | |
| PRSPb | DQ-113 | 0.004 | 7.601 (3.061-11.90) |
| Gatifloxacin | 0.25 | 64.69 (45.30-90.52) | |
| Ciprofloxacin | 0.5 | 125.9 (83.55-178.3) |
a
Groups of 10 mice each were infected intranasally with 0.05 ml of PSSP bacterial suspension (5 × 103 CFU/mouse).
b
Groups of 10 mice each were infected intranasally with 0.05 ml of PRSP bacterial suspension (5 × 106 CFU/mouse).