TABLE 3.

Quinolone MICs for 26 strains with defined mutations in the QRDR

Strain	HMCa no.	MIC (μg/ml)b						Detected mutation in QRDR of:
		DK-507k	Sita	Cipro	Lev	Gati	Moxi	GyrA	GyrB	ParC	ParE
1	1055	0.5	0.5	32	16	8	4	S81F		S79F, K137N	1460V
2	1059	0.25	0.25	16	8	2	2	S81F		D83N	1460N
3	1060	0.25	0.25	16	8	2	2	S81F		S79F, K137N	1460V
4	1066	0.5	0.25	>32	16	4	2	S81F		D83N
5	1068	1	0.5	32	32	8	4	S81F		S79F	1460V
6	1070	0.25	0.25	16	16	2	2	S81F		S79F, K137N	1460V
7	1071	0.25	0.25	32	16	4	2	S81A		S79Y
8	1073	0.5	1	16	32	8	2	S81C		S79F	1460V
9	1074	0.5	0.25	32	16	4	2	S81Y		S79F
10	1076	0.5	0.25	32	16	4	2		E474K	S79F, K137N	1460V
11	1077	0.5	0.5	>32	16	4	2	S81F, S114G		D83G, N91D
12	1078	0.5	0.5	>32	16	4	2	S81F		S79F, K137N	1460V
13	1150	0.25	0.25	16	8	2	1	S81F		S79F	1460V
14	1156	0.5	1	>32	32	8	4			S79Y
15	1062	1	1	>32	32	8	4	S81F		S79F	1460V
16	1072	0.25	0.5	32	16	4	2	S81F		S79F, K137N	1460V
17	1146	0.25	0.5	32	8	2	1	S81F		R95C	D435N
18	1147	0.5	0.5	>32	16	4	2	S81F		S79F, K137N	1460V
19	2527	0.25	0.25	16	8	2	2	S81Y		S79F	I460V
20	2529	0.25	0.25	16	8	2	1	S81Y		S79F	I460V
21	2578	0.25	0.25	4	16	2	2	S81Y		S79F	I460V
22	4026	0.5	0.5	32	16	4	1	S81Y		S79F	I460V
23	5041	0.25	0.5	16	16	4	2	S81F		S79F
24	2536	0.25	0.5	4	8	1	2	S81Y		S79F	I460V
25	2538	0.25	0.5	4	8	1	1	S81Y		S79F	I460V
26	2542	0.25	0.5	4	8	2	1	S81Y		S79F	I460V

^aHMC, Hershey Medical Center.

^bSita, sitafloxacin; Cipro, ciprofloxacin; Lev, levofloxacin; Gati, gatifloxacin; Moxi, moxifloxacin.