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. 2010 Oct 5;3:147–155. doi: 10.2147/ott.s12480

Figure 1.

Figure 1

Key molecular pathways in renal cell carcinoma pathogenesis and the points at which the currently approved agents function.

Abbreviations: HIF, hypoxia inducible factor; RCC, renal cell carcinoma; PDGF, platelet-derived growth factor; TK, tyrosine kinase; VEGF, vascular endothelial growth factor; VHL, von Hippel-Lindau protein.