Figure 1.
Key molecular pathways in renal cell carcinoma pathogenesis and the points at which the currently approved agents function.
Abbreviations: HIF, hypoxia inducible factor; RCC, renal cell carcinoma; PDGF, platelet-derived growth factor; TK, tyrosine kinase; VEGF, vascular endothelial growth factor; VHL, von Hippel-Lindau protein.