FIG. 1.

Survival times based on a a low-dose, galactosamine-sensitized mouse model of an acute, systemic E. coli infection. The survival time of the mice was 48 h (±5 h) upon triclosan treatment compared to only 8 h (±1 h) for untreated and 28 h (±3 h) and 24 h (±2 h) for ampicillin- and tetracycline-treated mice, respectively. Statistical significance was tested by one-way ANOVA (P < 0.001, n = 5). (Inset) Triclosan administration along with, instead of prior to, infection as well as intraperitoneal administration instead of subcutaneous administration also increased the survival time to 48 h.