Table 4.
Positive and Negative Syndrome Scale subscale score changes, by endpoint Drug Attitude Inventory response for all patients
| DAI item | Resp. |
Depressive |
Disorg. Tht. |
Hostility |
Negative |
Positive |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Pvalue | Mean (SD) | Pvalue | Mean (SD) | Pvalue | Mean (SD) | Pvalue | Mean (SD) | Pvalue | ||
| Good outweighs bad | No | −1.6 (4.0) | <0.001 | −2.1 (5.0) | <0.001 | −1.0 (4.9) | <0.001 | −2.6 (6.8) | <0.001 | −4.6 (8.5) | <0.001 |
| Yes | −3.2 (3.8) | −4.4 (4.9) | −2.6 (4.4) | −6.2 (7.3) | −10.0 (9.3) | ||||||
| Feel weird, like a “zombie” | No | −3.3 (3.9) | <0.001 | −4.3 (5.0) | <0.001 | −2.5 (4.6) | 0.014 | −6.1 (7.4) | <0.001 | −10.0 (9.3) | <0.001 |
| Yes | −1.8 (3.6) | −2.9 (5.0) | −1.7 (4.5) | −3.5 (6.8) | −6.4 (9.4) | ||||||
| Take meds of own free choice | No | −2.8 (4.0) | 0.59 | −3.6 (4.8) | 0.32 | −1.9 (4.9) | 0.25 | −4.3 (7.3) | 0.024 | −8.0 (9.6) | 0.10 |
| Yes | −3.0 (3.9) | −4.1 (5.0) | −2.4 (4.5) | −5.8 (7.3) | −9.5 (9.4) | ||||||
| Feel more relaxed | No | −2.0 (4.0) | <0.001 | −2.7 (4.8) | <0.001 | −1.3 (4.9) | <0.001 | −3.5 (7.6) | <0.001 | −6.2 (8.7) | <0.001 |
| Yes | −3.2 (3.8) | −4.4 (5.0) | −2.6 (4.4) | −6.2 (7.2) | −10.0 (9.5) | ||||||
| Feel tired/sluggish | No | −3.4 (4.0) | <0.001 | −4.6 (5.1) | <0.001 | −2.7 (4.6) | <0.001 | −6.6 (7.6) | <0.001 | −10.0 (9.4) | <0.001 |
| Yes | −2.2 (3.7) | −3.0 (4.8) | −1.7 (4.5) | −3.8 (6.6) | −7.1 (9.2) | ||||||
| Take meds only when sick | No | −3.2 (3.9) | 0.06 | −4.7 (5.2) | <0.001 | −2.9 (4.7) | <0.001 | −6.8 (7.4) | <0.001 | −11.0 (9.8) | <0.001 |
| Yes | −2.7 (3.9) | −3.2 (4.7) | −1.7 (4.4) | −4.2 (7.0) | −7.3 (8.7) | ||||||
| Feel more normal | No | −2.2 (4.5) | <0.001 | −2.9 (5.2) | <0.001 | −1.4 (5.3) | <0.001 | −3.9 (7.3) | <0.001 | −6.3 (9.6) | <0.001 |
| Yes | −3.2 (3.7) | −4.4 (4.9) | −2.7 (4.3) | −6.1 (7.3) | −10.0 (9.2) | ||||||
| Unnatural to be controlled by meds | No | −3.0 (4.0) | 0.58 | −3.9 (5.1) | 0.47 | −2.4 (4.4) | 0.89 | −5.9 (7.6) | 0.052 | −9.4 (9.6) | 0.62 |
| Yes | −2.9 (3.8) | −4.2 (4.9) | −2.3 (4.9) | −5.0 (6.9) | −9.1 (9.3) | ||||||
| Clearer thoughts | No | −2.1 (4.3) | <0.001 | −2.5 (4.6) | <0.001 | −1.1 (4.6) | <0.001 | −3.6 (6.5) | <0.001 | −5.8 (8.8) | <0.001 |
| Yes | −3.2 (3.7) | −4.5 (5.1) | −2.7 (4.5) | −6.2 (7.5) | −10.0 (9.4) | ||||||
| Med prevents sickness | No | −2.0 (4.4) | <0.001 | −2.3 (5.2) | <0.001 | −1.0 (4.6) | <0.001 | −3.7 (7.2) | <0.001 | −5.6 (8.9) | <0.001 |
| Yes | −3.2 (3.7) | −4.4 (4.9) | −2.6 (4.5) | −6.0 (7.3) | −10.0 (9.4) | ||||||
P value difference between percentages of patients responding “yes” or “no,” using Fisher’s Exact test.
Abbreviations: DAI, Drug Attitude Inventory; Disorg. Tht, disorganized thought subscale; SD, standard deviation; Resp, response.