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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Dev Dyn. 2010 Feb;239(2):548–558. doi: 10.1002/dvdy.22201

Figure 3. Inhibition of ChCh and Sip1a affects the components of the “clock and wavefront model”.

Figure 3

Flat mount RNA in situ hybridization of 10 somite stage wild type, ChCh and Sip1a compromised embryos(A–I). All views are dorsal; anterior to the left. In wildtype embryos, periodic activation of Notch signaling provides cycling gene expression of Notch pathway genes such as her1 and her7 (A–F). The number of the her7 expressing stripes in chch and sip1a ATG MO injected embryos ranges from 4 to 5 (B,C; E,F). fgf8 expression domain at tailbud is expanded anteriorly in ChCh and Sip1a compromised embryos (G–I). Asterisks denote each her1 or her7 expressing premesoderm stripe (A–F). Arrows denotes fgf8 tailbud expression domain (G–I).