Table 2.
Proteins identified by MALDI-TOF that showed significant (p<0.05) upregulation between RCC and the corresponding normal kidney tissue
| Spot ID | Histology | Protein name | Swiss-Prot Accession number | Fold-change | MW/pI (experimental) | MOWSE score | Number of peptides matched (Total no. of peptides) | Sequence coverage |
|---|---|---|---|---|---|---|---|---|
| CC1 | Clear Cell RCC | Heat shock protein 27 (Hsp27) | P04792 | 11.1 | 22,327 / 7.8 | 6.666e+04 | 11 (22) | 42% |
| CC2 | Clear Cell RCC | Triosephosphate isomerase 1 (TPI-1) | P60174 | 7.1 | 22,327 / 6.4 | 1.340e+04 | 8 (16) | 37% |
| CC3 | Clear Cell RCC | Beta globin (HBB) | P68873 | 10.9 | 15,999 / 6.7 | 4.982e+06 | 10 (20) | 76% |
| CC4 | Clear Cell RCC | Peroxiredoxin 2 (PRX-2) | P32119 | 2.1 | 21,892 / 5.6 | 3.237e+04 | 9 (18) | 36% |
| CC5 | Clear Cell RCC | Apolipoprotein A1 precursor (Apo-A1) | P02647 | 3.0 | 28,962 / 5.3 | 5.710e+07 | 17 (44) | 57% |
| CC6 | Clear Cell RCC | Ferritin Light polypeptide | Q6DMM8 | 8.9 | 20,020 / 5.5 | 4.726e+04 | 9 (19) | 42% |
| CC7 | Clear Cell RCC | Haptoglobin | P00738 | 8.0 | 38,234 / 6.1 | 200 | 5 (17) | 9% |
| CHR1 | Chromophobe RCC | ZnCu-Superoxide dismutase (SOD2) | Q7Z7M6 | 5.5 | 18,838 / 5.6 | 1134 | 5 (12) | 43% |
| CHR2 | Chromophobe RCC | UV excision repair protein RAD23B | P54727 | 11.8 | 43,172 / 4.9 | 1.053e+05 | 11(31) | 27% |
| CHR3 | Chromophobe RCC | Alpha-1 anti-trypsin (SERPINA1) | P01009 | 13.5 | 44,251 / 5.5 | 4.065e+04 | 8(22) | 23% |
| ONCO1 | Oncocytoma | Alpha-Enolase (ENOA) | P06733 | 10.4 | 49,703 / 7.1 | 9.403e+05 | 12(34) | 35% |