TABLE 1.
Gene | Gene function | mRNA decreasea | Transfected cell line | Ref. |
---|---|---|---|---|
CAPNS1 | Ca2+-dependent intracellular cysteine protease | 30% | HeLa | 33 |
Cyctochrome c | Oxidative phosphorylation | 75% | C2C12 | 39 |
COX5b | Oxidative phosphorylation | 70% | C2C12 | 39 |
MEF2A | Transcription factor | 67% | C2C12 | 39 |
COX mRNAs: 4il, 5a, 5b, 6a1, 6b, 6c, 7a2, 7b 7c, 8a | Oxidative phosphorylation | 40–75% | N2a | 38 |
TFAM, TFB1M, TFB2M | Transcription of mitochondrial genes | 35–70% | N2a | 38 |
SURF1 | Surfeit1- involved in the COX complex | 35–70% | N2a | 38 |
VDAC1 | Voltage-dependent anion channel | 35–70% | N2a | 38 |
TOM20 | Mitochondrial protein transporter | 35–70% | N2a | 38 |
a Decrease in mRNA levels following NRF-1 knockdown.