TABLE 1.

The extent of decrease in NRF-1 target genes following NRF-1 knockdown

Gene	Gene function	mRNA decreasea	Transfected cell line	Ref.
CAPNS1	Ca2+-dependent intracellular cysteine protease	30%	HeLa	33
Cyctochrome c	Oxidative phosphorylation	75%	C2C12	39
COX5b	Oxidative phosphorylation	70%	C2C12	39
MEF2A	Transcription factor	67%	C2C12	39
COX mRNAs: 4il, 5a, 5b, 6a1, 6b, 6c, 7a2, 7b 7c, 8a	Oxidative phosphorylation	40–75%	N2a	38
TFAM, TFB1M, TFB2M	Transcription of mitochondrial genes	35–70%	N2a	38
SURF1	Surfeit1- involved in the COX complex	35–70%	N2a	38
VDAC1	Voltage-dependent anion channel	35–70%	N2a	38
TOM20	Mitochondrial protein transporter	35–70%	N2a	38

^a Decrease in mRNA levels following NRF-1 knockdown.