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Effects of PARP-1 inhibition of boosting of the kynurenine pathway on the effects of FK866 on NAD contents in various mouse organs. Mice were injected intraperitoneally with FK866 (100 mg/kg) and subcutaneously with PARP-1 inhibitors PJ34 (10 mg/kg) or kynurenine (100 mg/kg) and NAD contents were measured in different tissues 8 h later. Each column represents the mean ± S.E. of 5 mice. *, p < 0.05 versus vehicle. Analysis of variance and Tukey's post hoc test was used.
