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. 2010 Aug 2;285(44):34181–34190. doi: 10.1074/jbc.M110.128355

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — a, natural collagenase cleavage sites in human types I-III collagens. The triplet containing the cleavage scissile bond is colored in red. Conserved residues, including two imino acids in the two triplets immediately preceding the cleavage sites, are highlighted in the box. The two triplets immediately following the cleavage sites do not contain any imino acids, except one Hyp (colored in green) in the α2 chain of type I collagen. b, 5-triplet model of the collagenase cleavage sites in the α1 chain of types I-III collagen. The cleavage triplet GIA/GLA requires the presence of two imino acid triplets preceding the cleavage site as well as two non-imino acid triplets following the cleavage site. The cleavage triplet GLL in the α2 chain of type I collagen shows a different pattern.