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Model of leukemic transformation in MPD. Some patients develop JAK2V617F+ AML after JAK2V617F+ MPD, consistent with a JAK2V617F+ progenitor that undergoes leukemic transformation. However, some patients with JAK2V617F+ MPD transform to a JAK2V617F− AML, consistent with a “pre-JAK2” clone, which is susceptible to leukemic transformation. Illustration by Debra Tyler.
