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. Author manuscript; available in PMC: 2010 Oct 22.
Published in final edited form as: Transplantation. 1992 May;53(5):1056–1062. doi: 10.1097/00007890-199205000-00017

Table 8.

Cause of graft failure under FK506 as a function of the reason for conversion from CsA

Cause of graft failure Entry diagnosis
ACR CR CR/hep. Hep. Other Total
Acute rejection 0 0 0 0 0 0
Chronic rejection 1 7 2 0 0 10
Hepatitis 0 0 1 1 0 2
Biliary tract problem 0 2a 0 0 0 2
Hepatic artery thrombosis 0 1b 0 0 0 1
Other 0 1c 1d 0 1e 3
Totals 1 11 4 1 1 18
a

Examination of the failed graft revealed biliary sludge in the deep hilar region and focal duct loss without arteriopathy.

b

The patient initially responded to FK506, but the graft failed because of thrombosis at the arterial suture line.

c

The cause of failure is uncertain. Severe sclerosis of terminal hepatic venules and early cirrhosis were found in the failed graft.

d

There was severe atherosclerosis of arterial graft and hepatitis.

e

There was a mistaken pathologic diagnosis; a portal vein-bile duct fistula was found in failed graft that was missed on pre-FK biopsy.