TABLE 1.
Patients, interferon treatment, and outcome
| Patient | Age | Baseline Cr (mg/100 ml) | Rejection-free interval (mo) | INF dose (3×weekly) | Mos Rx | Interval to rejection (mo) | Cr at rejection (mg/100 ml) | Therapy and outcome |
|---|---|---|---|---|---|---|---|---|
| Group 1 | ||||||||
| 1 | 51 | 1.8 | 19 | 2×106 | 1.5 | 1.5 | 5.8 | Steroid recycle,a hemodialysis |
| 2 | 39 | 1.3 | 9 | (a) 5×106 | 6 | 8 | 5.1 | Steroid recycle, Cr stabilized |
| (b) 10×106 | 0.5 | 0.5 | 7.5 | Steroid recycle, hemodialysis | ||||
| 3 | 33 | 3.8 | 56 | 3×106 | 3 | 3 | 8.0 | Steroid recycle, hemodialysis |
| 4 | 25 | 1.7 | 14 | 5×106 | 6 | 5 | 2.3 | Steroid recycle ↓ INF to 3×106 Cr stabilized × 1 mo, then hemodialysis |
| 5 | 38 | 1.0 | 66 | 3×106 | 2.5 | 2 | 3.0 | Steroid recycle, ↑ CsA, hemodialysis |
| 6 | 34 | 1.2 | 21 | 5×106 | 0.3 | 0.3 | 3.7 | Steroid recycle, IV FK, Cr required intermittent hemodialysis, stabilized at Cr 2.5 |
| 7 | 25 | 2.4 | 36 | (a)5×106 | 5 | — | — | Stable renal function (Cr 2.0) at 36-mo follow-up |
| (b)3×106 | 5 | — | — | |||||
| (c)5×106 | 3 | — | — | |||||
| Group2 | ||||||||
| 8 | 37 | 1.8 | 9 | 3×106 | 2.5 | 2.5 | 6.1 | Steroid recycle, IV FK, hemodialysis |
| 9 | 24 | 1.7 | 25 | 1.5×106 | 1.5 | — | — | Discontinued for systemic side effects, renal function stable |
| 10 | 67 | 1.6 | 18 | 3×106 | 2.5 | — | — | Still on Rx |
| 11 | 46 | 1.8 | 40 | 5×I06 | 6 | — | — | Stable renal function 2-yr follow-up |
a
An 8-day tapering course of prednisone was started at 200 mg daily