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. Author manuscript; available in PMC: 2010 Oct 22.
Published in final edited form as: Oncogene. 2010 Aug 23;29(42):5653–5662. doi: 10.1038/onc.2010.367

Figure 1. Differentiation of T cell subsets.

Figure 1

Upon activation naïve CD4+ T cells can differentiate into Th1, Th2, Th17 or Treg cells directed by the local inflammatory milieu. TGF-β and IL-6 induce Th17 cell polarisation characterised by the production of IL-17, IL-21 and IL-22 and the transcriptional factor RORγt.