Table 1.
APP/PS1 |
Plaq./Tiss. | APP/PS1 Plaq. | WT | ||
---|---|---|---|---|---|
APP/PS1 Tiss. vs. | |||||
Region | Plaquea | Tissuea | Ratio | vs Tiss p-valueb | Tissuea |
WT Tiss. p-value c | |||||
Cortex | 153.6 ± 2.6 ns |
222.8 ± 1.8 | 0.69 ± 0.01 | 0.001 | 219.2 ± 0.4 |
Hippocampus | 153.8 ± 2.8 ns |
218.7 ± 1.0 | 0.70 ± 0.01 | 0.001 | 215.9 ± 0.8 |
Thalamus | 11.8 ± 0.2 0.001 |
215.7 ± 2.1 | 0.055 ± 0.001 | 0.001 | 201.4 ± 1.4 |
Mean (± SEM) gray level value of n=10 plaques or adjacent tissue ROIs per region measured in 8-bit gray scale images of DAB-enhanced Prussian blue stained histological sections from a 24-month old APP/PS1 or age-matched WT mouse. Lower gray level value indicates darker staining and relatively higher iron content.
Two-way ANOVA APP/PS1 Plaque vs. Tissue Iron Densitometry: Plaque vs. Tissue – F(1,59)=4874.35, p<0.001; Region - F(2,59)=921.83, p<0.001; Plaq./Tiss. × Reg. Interaction – F(2,59)=799.64, p<0.001; Student-Newman-Keuls multiple comparisons.
Two-way ANOVA APP/PS1 Tissue vs. WT Tissue Iron Densitometry: AD vs. WT – F(1,59)=37.13, p<0.001; Region - F(2,59)=42.50, p<0.001; AD/WT × Reg. Interaction – F(2,59)=10.72, p<0.001; Student-Newman-Keuls multiple comparisons.