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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Exp Hematol. 2010 Jul 14;38(11):1006–1013. doi: 10.1016/j.exphem.2010.07.001

Figure 2.

Figure 2

Reduction in LC mRNAs in siRNA transfected mouse and human myeloma cells. (A) SP2/O-λ6 cells treated with siRNA specific for the V or J portions of λ6 light chain Wil or to the Cλ region. (B) 8226 cells treated with siRNA directed to either the V- or C-terminus of λ LC 8226. The gene expression levels of LCs Wil and 8226 at 24, 48, and 72 hours were quantified by RT-PCR using murine GAPDH as a calibrator gene (performed in triplicate). Bars indicate the expression of treated versus sham siRNA treated cells as the mean ± SEM of 3 representative experiments.