Table 2.

Effect of PMA and TBT exposures on human NK cell-surface protein expression

Treatment	Mean Fluorescence Intensity (Percent of Control)
	CD2	CD11a	CD16	CD18	CD56
2.5 nM (24 h Exposure)	NS	30±22	17±5	37±23	50±10
5 nM (1 h exposure followed by 24 h in PMA-free medium)	NS	32±10	11±5	31±8	NS
2.5 nM (1 h exposure followed by 24 h in PMA-free medium)	NS	28±4	16±12	35±3	54±3
1 nM (1 h exposure followed b y 24 h in PMA-free medium)	NS	62±15	47±15	67±18	NS
0.5 nM (1 h exposure followed by 24 h in PMA-free medium)	NS	NS	NS	NS	NS
PD + 1 nM (1 h exposure followed by 24 h in PMA-free medium)	NS	NS	NS	NS	NS
300 nM TBT (1 h exposure followed by 24 h in TBT-free media)	NS	NS	70±12	89±1	62±11
200 nM TBT (1 h exposure followed by 24 h in TBT-free media)	NS	NS	82±9	NS	76±5
PD +300 nM TBT (1 h exposure followed by 24 h in TBT-free media)	NS	NS	NS	NS	75±11

NS- indicates no significant change compared to control. All other changes are significant p<0.05.Values are the mean±S.D. of at least three determination (n≥3) from cells prepared from different donors. PD=MAPK Kinase (MAP2K) inhibitor PD98059