Decreased 5-methylcytosine and p66α nuclear immunoreactivity in entorhinal cortex layer II island neurons that were immunoreactive for the late-stage tangle markers PS396 and PHF1. A1) 5-methylcytosine immunoreactivity, AD case. A2) Same field, PS396 immunoreactivity. A3) Merged image. B1) 5-methylcytosine immunoreactivity, ND case. B2) Same field, PS396 immunoreactivity. B3) Merged image. C1) p66α immunoreactivity, AD case. C2) Same field, PHF1 immunoreactivity. C3) Merged image. D1) p66α immunoreactivity, ND case. D2) Same field, PHF1 immunoreactivity. D3) Merged image.