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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Exp Eye Res. 2010 Aug 13;91(5):640–651. doi: 10.1016/j.exer.2010.08.006

Figure 5.

Figure 5

Activation of JNK and p38 stress pathways in αA−/− lens epithelial and fiber cells. Lens epithelial (LE) and cortical fiber cell (LC) fractions were dissected from 18–20 wild-type (WT) or αA−/− mouse lenses. Cell extracts were examined by immunoblot analysis with antibodies to (A) p-JNK and JNK, and (B) p-p38 and p38. Note that while p38 and JNK were activated in lens epithelial and cortical fiber cells of αA−/− mice, the degree of activation of these stress kinases was much greater in the cortical fiber zone of αA−/− lenses. Protein bands were quantified, and ratios of activated to total protein were determined and presented as fold-change between αA−/− and WT lenses. The results are representative of three independent experiments.